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Lesley-Ann Martin, MD

Breast Cancer Now Toby Robins Research Centre, 
The Institute of Cancer Research, London, UK

Lesley-Ann Martin is Senior Staff Scientist and Group Leader within the Breast Cancer Now Tony Robins Research Centre at The Institute of Cancer Research, London, UK. She receives funding from Breast Cancer Now along with Professor Mitch Dowsett. 

Dr Martin’s main interest is the treatment of the most common type of breast cancer, known as hormone-receptor- or oestrogen-receptor-positive cancer. Such tumours account for around three in every four breast cancers and they can be treated with endocrine agents such as tamoxifen and aromatase inhibitors. Although these treatments are generally effective initially, patients often develop resistance to them. Together with Professor Dowsett, she is trying to identify the phenotypic and genotypic alterations that influence response or resistance to endocrine therapy, and to translate these molecular findings into novel treatments. Her group has developed a panel of breast cancer cell lines that model clinical scenarios. By using technologies such as global proteomics, RNA-seq, and chromatin immunprecipitation (ChIP-seq), they are beginning to build a picture of the mechanisms of endocrine resistance. These models are giving an insight into oestrogen receptor biology and providing a platform in which to investigate clinical targets and to test new therapeutic strategies, many of which make their way into clinical trials.

Dr Martin has published more than 120 articles in peer-reviewed journals such as Breast Cancer Research, PLos ONE, Annals of Oncology, and Cancer Research. She holds a number of academic industrial awards as well as a Global Alliance award as part of an initiative with AstraZeneca. Dr Martin also sits on a number of advisory boards.